1h19 Summary



The structure was published by Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., and Haeggstrom, J.Z., in 2002 in a paper entitled "Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of LEUKOTRIENE A-4 HYDROLASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LEUKOTRIENE A-4 HYDROLASE P09960 (2-611) (LKHA4_HUMAN)search Homo sapienssearch 100% 611 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09960 (2 - 611) LEUKOTRIENE A-4 HYDROLASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P09960) Leukotriene A4 hydrolase C-terminal domainsearch, Leukotriene A4 hydrolase N-terminal domainsearch, Leukotriene A4 hydrolase catalytic domainsearch Neutral Protease Domain 2search PF01433: Peptidase family M1search, PF09127: Leukotriene A4 hydrolase, C-terminalsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P09960) leukotriene-A4 hydrolase activitysearch peptidase activitysearch hydrolase activitysearch zinc ion bindingsearch metallopeptidase activitysearch epoxide hydrolase activitysearch aminopeptidase activitysearch metal ion bindingsearch poly(A) RNA bindingsearch leukotriene biosynthetic processsearch proteolysissearch arachidonic acid metabolic processsearch peptide catabolic processsearch small molecule metabolic processsearch inflammatory responsesearch leukotriene metabolic processsearch cytosolsearch nucleolussearch cytoplasmsearch extracellular vesicular exosomesearch nucleussearch

Chain InterPro annotation
A Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolasesearch Leukotriene A4 hydrolasesearch Peptidase M1, membrane alanine aminopeptidase, N-terminalsearch Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminalsearch Armadillo-type foldsearch