1gzx Summary

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OXY T STATE HAEMOGLOBIN: OXYGEN BOUND AT ALL FOUR HAEMS

The structure was published by Paoli, M., Liddington, R., Tame, J., Wilkinson, A., and Dodson, G., in 1996 in a paper entitled "Crystal Structure of T State Haemoglobin with Oxygen Bound at All Four Haems." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch small molecule metabolic processsearch transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolsearch cytosolic small ribosomal subunitsearch membranesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch
B, D (P68871) oxygen bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen transportsearch blood coagulationsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch renal absorptionsearch positive regulation of nitric oxide biosynthetic processsearch transportsearch regulation of blood pressuresearch regulation of blood vessel sizesearch nitric oxide transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch oxidation-reduction processsearch platelet aggregationsearch small molecule metabolic processsearch positive regulation of cell deathsearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch