1gzl Summary

pdbe.org/1gzl
spacer

CRYSTAL STRUCTURE OF C14LINKMID/IQN17: A CROSS-LINKED INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 HYDROPHOBIC POCKET

The structure was published by Sia, S.K., Carr, P.A., Cochran, A.G., Malashkevich, V.M., and Kim, P.S., in 2002 in a paper entitled "Short Constrained Peptides that Inhibit HIV-1 Entry" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI and ENVELOPE GLYCOPROTEIN GP41.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI P03069 (249-276) (GCN4_YEAST)search ,
P04578 (565-581) (ENV_HV1H2)search
Saccharomyces cerevisiae S288csearch ,
HIV-1 M:B_HXB2Rsearch
< 90% ,
< 90%
46 100%
B FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI P03069 (249-276) (GCN4_YEAST)search ,
P04578 (565-581) (ENV_HV1H2)search
Saccharomyces cerevisiae S288csearch ,
HIV-1 M:B_HXB2Rsearch
< 90% ,
< 90%
46 100%
C ENVELOPE GLYCOPROTEIN GP41 P04578 (628-639) (ENV_HV1H2)search HIV-1 M:B_HXB2Rsearch < 90% 12 100%
D ENVELOPE GLYCOPROTEIN GP41 P04578 (628-639) (ENV_HV1H2)search HIV-1 M:B_HXB2Rsearch < 90% 12 100%


Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Virus ectodomainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch, Retroviral envelope proteinsearch
C, D Virus ectodomainsearch Retroviral envelope proteinsearch