1gzk Summary

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MOLECULAR MECHANISM FOR THE REGULATION OF PROTEIN KINASE B/ AKT BY HYDROPHOBIC MOTIF PHOSPHORYLATION

The structure was published by Yang, J., Cron, P., Thompson, V., et al., Hess, D., Hemmings, B.A., and Barford, D., in 2002 in a paper entitled "Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RAC-BETA SERINE/THREONINE PROTEIN KINASE. This molecule has the UniProt identifier P31751 (AKT2_HUMAN)search. The sample contained 315 residues which is < 90% of the natural sequence. Out of 315 residues 266 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RAC-BETA SERINE/THREONINE PROTEIN KINASE P31751 (146-460) (AKT2_HUMAN)search Homo sapienssearch < 90% 315 86%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P31751 (146 - 460) RAC-BETA SERINE/THREONINE PROTEIN KINASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P31751) protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch