1gzg Summary

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COMPLEX OF A MG2-DEPENDENT PORPHOBILINOGEN SYNTHASE FROM PSEUDOMONAS AERUGINOSA (MUTANT D139N) WITH 5-FLUOROLEVULINIC ACID

The structure was published by Frere, F., Schubert, W.-D., Stauffer, F., et al., Neier, R., Jahn, D., and Heinz, D.W., in 2002 in a paper entitled "Structure of Porphobilinogen Synthase from Pseudomonas Aeruginosa in Complex with 5-Fluorolevulinic Acid Suggests a Double Schiff Base Mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.66 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of DELTA-AMINOLEVULINIC ACID DEHYDRATASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DELTA-AMINOLEVULINIC ACID DEHYDRATASE Q59643 (1-337) (HEM2_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 337 97%
B DELTA-AMINOLEVULINIC ACID DEHYDRATASE Q59643 (1-337) (HEM2_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 337 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q59643 (1 - 337) DELTA-AMINOLEVULINIC ACID DEHYDRATASE Pseudomonas aeruginosa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q59643) 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)search Aldolase class Isearch PF00490: Delta-aminolevulinic acid dehydratasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q59643) tetrapyrrole biosynthetic processsearch porphyrin-containing compound biosynthetic processsearch protoporphyrinogen IX biosynthetic processsearch heme biosynthetic processsearch porphobilinogen synthase activitysearch catalytic activitysearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, B Porphobilinogen synthasesearch Aldolase-type TIM barrelsearch