› 1gz9

X-ray diffraction
1.7Å resolution

High-Resolution Crystal Structure of Erythrina cristagalli Lectin in Complex with 2'-alpha-L-Fucosyllactose

Released:
DOI: 10.2210/pdb1gz9/pdb
PDB entry 1gz9 coloured by chain, front view.
PDB entry 1gz9 coloured by chain, side view.
PDB entry 1gz9 coloured by chain, top view.
Source organism: Erythrina crista-galli
Primary publication:
High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data.
Svensson C, Teneberg S, Nilsson CL, Kjellberg A, Schwarz FP, Sharon N, Krengel U
J Mol Biol 321 69-83 (2002)
PMID: 12139934

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160691 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Lectin Chain: A
Molecule details ›
Chain: A
Length: 239 amino acids
Theoretical weight: 26.25 KDa
Source organism: Erythrina crista-galli
UniProt:
  • Canonical: P83410 (Residues: 1-239; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL, FUC
Carbohydrate polymer
2 bound ligands:
Ligand MN 1 x MN
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P43212
Unit cell:
a: 80.9Å b: 80.9Å c: 125.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.239

Quick links

Citations

2 review citations

Applications of calorimetric methods to drug discovery and the study of protein interactions.
Weber et al. (2003)
1 more

4 mentions without citation

Legume Lectins: Proteins with Diverse Applications.
Lagarda-Diaz et al. (2017)
3 more