1gz8 Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 2-AMINO-6-(3'-METHYL-2'-OXO)BUTOXYPURINE

The structure was published by Gibson, A.E., Arris, C.E., Bentley, J., et al., Noble, M.E., Tucker, J.A., and Whitfield, H.J., in 2002 in a paper entitled "Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) positive regulation of DNA-dependent DNA replication initiationsearch meiotic nuclear divisionsearch regulation of gene silencingsearch Ras protein signal transductionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch histone phosphorylationsearch cell cyclesearch G2/M transition of mitotic cell cyclesearch positive regulation of cell proliferationsearch protein phosphorylationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch phosphorylationsearch potassium ion transportsearch mitotic G1 DNA damage checkpointsearch mitotic nuclear divisionsearch cell divisionsearch G1/S transition of mitotic cell cyclesearch DNA repairsearch centrosome duplicationsearch cellular response to nitric oxidesearch cellular response to DNA damage stimulussearch positive regulation of transcription, DNA-templatedsearch DNA replicationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic cell cyclesearch blood coagulationsearch protein bindingsearch kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch histone kinase activitysearch cyclin bindingsearch nucleotide bindingsearch metal ion bindingsearch transferase activitysearch nucleoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleussearch cytoplasmsearch condensed chromosomesearch cytosolsearch chromosome, telomeric regionsearch endosomesearch cytoskeletonsearch X chromosomesearch Y chromosomesearch centrosomesearch Cajal bodysearch microtubule organizing centersearch transcription factor complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch