1gz8 Summary

pdbe.org/1gz8
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 2-Amino-6-(3'-methyl-2'-oxo)butoxypurine

The structure was published by Gibson, A.E., Arris, C.E., Bentley, J., et al., Noble, M.E., Tucker, J.A., and Whitfield, H.J., in 2002 in a paper entitled "Probing the ATP Ribose-Binding Domain of Cyclin-Dependent Kinases 1 and 2 with O(6)-Substituted Guanine Derivatives" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch histone kinase activitysearch cyclin bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch protein kinase activitysearch transferase activitysearch metal ion bindingsearch protein phosphorylationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch meiotic cell cyclesearch potassium ion transportsearch phosphorylationsearch cell cyclesearch mitotic G1 DNA damage checkpointsearch mitotic nuclear divisionsearch positive regulation of transcription, DNA-templatedsearch centrosome duplicationsearch cellular response to nitric oxidesearch cell divisionsearch cellular response to DNA damage stimulussearch DNA replicationsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch meiotic nuclear divisionsearch Ras protein signal transductionsearch mitotic cell cyclesearch blood coagulationsearch regulation of gene silencingsearch positive regulation of cell proliferationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch transcription factor complexsearch cytoplasmsearch endosomesearch nucleoplasmsearch cytosolsearch nucleussearch condensed chromosomesearch centrosomesearch microtubule organizing centersearch chromosome, telomeric regionsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch Y chromosomesearch cytoskeletonsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch