1gxc Summary

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FHA DOMAIN FROM HUMAN CHK2 KINASE IN COMPLEX WITH A SYNTHETIC PHOSPHOPEPTIDE

The structure was published by Li, J., Williams, B.L., Haire, L.F., et al., Yaffe, M.B., Jackson, S.P., and Smerdon, S.J., in 2002 in a paper entitled "Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SERINE/THREONINE-PROTEIN KINASE CHK2 and SYNTHETIC PHOSPHOPEPTIDE.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SERINE/THREONINE-PROTEIN KINASE CHK2 O96017 (64-212) (CHK2_HUMAN)search Homo sapienssearch < 90% 149 77%
D SERINE/THREONINE-PROTEIN KINASE CHK2 O96017 (64-212) (CHK2_HUMAN)search Homo sapienssearch < 90% 149 77%
G SERINE/THREONINE-PROTEIN KINASE CHK2 O96017 (64-212) (CHK2_HUMAN)search Homo sapienssearch < 90% 149 77%
J SERINE/THREONINE-PROTEIN KINASE CHK2 O96017 (64-212) (CHK2_HUMAN)search Homo sapienssearch < 90% 149 77%
B SYNTHETIC PHOSPHOPEPTIDE Not available
Not available Not available 10 80%
E SYNTHETIC PHOSPHOPEPTIDE Not available
Not available Not available 10 80%
H SYNTHETIC PHOSPHOPEPTIDE Not available
Not available Not available 10 80%
K SYNTHETIC PHOSPHOPEPTIDE Not available
Not available Not available 10 80%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O96017 (64 - 212) SERINE/THREONINE-PROTEIN KINASE CHK2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D, G, J FHA domainsearch Tumour Suppressor Smad4search FHA domainsearch
B, E, H, K
Chain InterPro annotation
A, D, G, J Forkhead-associated (FHA) domainsearch SMAD/FHA domainsearch
B, E, H, K