1gwz Summary

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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1

The structure was published by Yang, J., Liang, X., Niu, T., Meng, W., Zhao, Z., and Zhou, G.W., in 1998 in a paper entitled "Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of SHP-1. This molecule has the UniProt identifier P29350 (PTN6_HUMAN)search. The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 275 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SHP-1 P29350 (243-541) (PTN6_HUMAN)search Homo sapienssearch 100% 299 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29350 (243 - 541) SHP-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P29350) Higher-molecular-weight phosphotyrosine protein phosphatasessearch Protein tyrosine phosphatase superfamilysearch PF00102: Protein-tyrosine phosphatasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (P29350) dephosphorylationsearch protein dephosphorylationsearch phosphatase activitysearch protein tyrosine phosphatase activitysearch

Chain InterPro annotation
A Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch