1gwx Summary



The structure was published by Xu, H.E., Lambert, M.H., Montana, V.G., et al., Willson, T.M., Kliewer, S.A., and Milburn, M.V., in 1999 in a paper entitled "Molecular recognition of fatty acids by peroxisome proliferator-activated receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1999.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (PPAR-DELTA).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (PPAR-DELTA) Q03181 (171-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 271 100%
B PROTEIN (PPAR-DELTA) Q03181 (171-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 271 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03181 (171 - 441) PROTEIN (PPAR-DELTA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q03181) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, betasearch Nuclear hormone receptor, ligand-bindingsearch