1gwr Summary

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HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE

The structure was published by Warnmark, A., Treuter, E., Gustafsson, J.-A., Hubbard, R.E., Brzozowski, A.M., and Pike, A.C.W., in 2002 in a paper entitled "Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely OESTROGEN RECEPTOR and TRANSCRIPTION INTERMEDIARY FACTOR-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A OESTROGEN RECEPTOR P03372 (305-549) (ESR1_HUMAN)search Homo sapienssearch < 90% 245 97%
B OESTROGEN RECEPTOR P03372 (305-549) (ESR1_HUMAN)search Homo sapienssearch < 90% 245 97%
C TRANSCRIPTION INTERMEDIARY FACTOR-2 Q15596 (742-750) (NCOA2_HUMAN)search Homo sapienssearch < 90% 9 100%
D TRANSCRIPTION INTERMEDIARY FACTOR-2 Q15596 (742-750) (NCOA2_HUMAN)search Homo sapienssearch < 90% 9 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (305 - 549) OESTROGEN RECEPTOR Homo sapiens
Q15596 (742 - 750) TRANSCRIPTION INTERMEDIARY FACTOR-2 HOMO SAPIENS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P03372) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch nucleussearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D