1guf Summary

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ENOYL THIOESTER REDUCTASE FROM CANDIDA TROPICALIS

The structure was published by Airenne, T.T., Torkko, J.M., Van Der Plas, S., et al., Kastaniotis, A.J., Wierenga, R.K., and Hiltunen, J.K., in 2003 in a paper entitled "Structure-Function Analysis of Enoyl Thioester Reductase Involved in Mitochondrial Maintenance" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH, B-SPECIFIC] 1, MITOCHONDRIAL.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH, B-SPECIFIC] 1, MITOCHONDRIAL Q8WZM3 (23-386) (ETR1_CANTR)search Candida tropicalissearch 94% 364 100%
B ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH, B-SPECIFIC] 1, MITOCHONDRIAL Q8WZM3 (23-386) (ETR1_CANTR)search Candida tropicalissearch 94% 364 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8WZM3 (23 - 386) ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADPH, B-SPECIFIC] 1, MITOCHONDRIAL Candida tropicalis

Chain Structural classification (SCOP) Structural classification (CATH)
A, B (Q8WZM3) Alcohol dehydrogenase-like, N-terminal domainsearch, Alcohol dehydrogenase-like, C-terminal domainsearch Medium-chain alcohol dehydrogenases, catalytic domainsearch, NAD(P)-binding Rossmann-like Domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q8WZM3) fatty acid metabolic processsearch oxidation-reduction processsearch lipid metabolic processsearch fatty acid biosynthetic processsearch mitochondrionsearch trans-2-enoyl-CoA reductase (NADPH) activitysearch enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activitysearch oxidoreductase activitysearch

Chain InterPro annotation
A, B Alcohol dehydrogenase superfamily, zinc-typesearch GroES (chaperonin 10)-likesearch NAD(P)-binding domainsearch