› 1gtq

X-ray diffraction
2.3Å resolution

6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE

Released:
DOI: 10.2210/pdb1gtq/pdb
PDB entry 1gtq coloured by chain, front view.
PDB entry 1gtq coloured by chain, side view.
PDB entry 1gtq coloured by chain, top view.
Source organism: Rattus rattus
Primary publication:
Three-dimensional structure of 6-pyruvoyl tetrahydropterin synthase, an enzyme involved in tetrahydrobiopterin biosynthesis.
Nar H, Huber R, Heizmann CW, Thöny B, Bürgisser D
EMBO J 13 1255-62 (1994)
PMID: 8137809

Function and Biology Details

Reaction catalysed: 
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
6-pyruvoyl tetrahydrobiopterin synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 140 amino acids
Theoretical weight: 15.88 KDa
Source organism: Rattus rattus
Expression system: Escherichia coli
UniProt:
  • Canonical: P27213 (Residues: 5-144; Coverage: 97%)
Gene name: Pts
Sequence domains: 6-pyruvoyl tetrahydropterin synthase
Structure domains: 6-pyruvoyl tetrahydropterin synthase/QueD

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P321
Unit cell:
a: 122.3Å b: 122.3Å c: 61.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.204 not available
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Tetrahydrobiopterin biosynthesis, regeneration and functions.
Thöny et al. (2000)
4 more

1 mention without citation

Purification, crystallization and preliminary crystallographic analysis of a 6-pyruvoyltetrahydropterin synthase homologue from Esherichia coli.
Seo et al. (2008)