1gt0 Summary

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Crystal structure of a POU/HMG/DNA ternary complex

The structure was published by Remenyi, A., Lins, K., Nissen, L.J., Reinbold, R., Scholer, H.R., and Wilmanns, M., in 2003 in a paper entitled "Crystal Structure of a POU/Hmg/DNA Ternary Complex Suggests Differential Assembly of Oct4 and Sox2 on Two Enhancers" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This entry contains 8 copies of 4 unique biopolymers (complete list).

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C OCTAMER-BINDING TRANSCRIPTION FACTOR 1 P14859 (280-438) (PO2F1_HUMAN)search Homo sapienssearch < 90% 159 86%
D TRANSCRIPTION FACTOR SOX-2 P48432 (41-120) (SOX2_MOUSE)search Mus musculussearch < 90% 80 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P14859 (280 - 438) OCTAMER-BINDING TRANSCRIPTION FACTOR 1 Homo sapiens
P48432 (41 - 120) TRANSCRIPTION FACTOR SOX-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C Homeodomainsearch, POU-specific domainsearch lambda repressor-like DNA-binding domainssearch, Homeodomain-likesearch Homeobox domainsearch, Pou domain - N-terminal to homeobox domainsearch
D HMG-boxsearch DNA Binding (I), subunit Asearch HMG (high mobility group) boxsearch, SOX transcription factorsearch

Chain ID Molecular function (GO) Biological process (GO)
C (P14859) sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch sequence-specific DNA bindingsearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
C POU-specificsearch Homeobox domainsearch Homeodomain-likesearch Lambda repressor-like, DNA-binding domainsearch POU domainsearch Homeobox, conserved sitesearch
D High mobility group box domainsearch