1grv Summary

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HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE FROM E. COLI

The structure was published by Guddat, L.W., Vos, S., Martin, J.L., Keough, D.T., and De Jersey, J., in 2002 in a paper entitled "Crystal Structures of Free, Imp-, and Gmp- Bound Escherichia Coli Hypoxanthine Phosphoribosyltransferase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE P0A9M2 (1-178) (HPRT_ECOLI)search Escherichia coli K-12search 100% 182 92%
B HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE P0A9M2 (1-178) (HPRT_ECOLI)search Escherichia coli K-12search 100% 182 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A9M2 (1 - 178) HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P0A9M2) Phosphoribosyltransferases (PRTases)search Rossmann foldsearch PF00156: Phosphoribosyl transferase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P0A9M2) GMP salvagesearch adenine salvagesearch IMP salvagesearch purine ribonucleoside salvagesearch hypoxanthine metabolic processsearch guanine salvagesearch nucleoside metabolic processsearch cytoplasmsearch cytosolsearch guanine phosphoribosyltransferase activitysearch transferase activitysearch hypoxanthine phosphoribosyltransferase activitysearch nucleotide bindingsearch magnesium ion bindingsearch transferase activity, transferring glycosyl groupssearch metal ion bindingsearch

Chain InterPro annotation
A, B Phosphoribosyltransferase domainsearch Hypoxanthine phosphoribosyl transferasesearch Phosphoribosyltransferase-likesearch