1gqm Summary

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THE STRUCTURE OF S100A12 IN A HEXAMERIC FORM

The structure was published by Moroz, O.V., Antson, A.A., Dodson, E.J., et al., Wilson, K.S., Lukanidin, E., and Bronstein, I.B., in 2002 in a paper entitled "The Structure of S100A12 in a Hexameric Form and its Proposed Role in Receptor Signalling" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of CALGRANULIN C.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
B CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
C CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
D CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
E CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
F CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
G CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
H CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
I CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
J CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
K CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%
L CALGRANULIN C P80511 (2-92) (S10AC_HUMAN)search Homo sapienssearch 99% 91 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80511 (2 - 92) CALGRANULIN C Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L (P80511) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G, H, I, J, K, L (P80511) cytoplasmsearch cytoskeletonsearch nucleussearch extracellular regionsearch membranesearch cytosolsearch plasma membranesearch immune system processsearch neutrophil chemotaxissearch monocyte chemotaxissearch xenobiotic metabolic processsearch defense response to fungussearch inflammatory responsesearch defense response to bacteriumsearch cytokine secretionsearch innate immune responsesearch killing of cells of other organismsearch positive regulation of NF-kappaB transcription factor activitysearch mast cell activationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch positive regulation of MAP kinase activitysearch positive regulation of inflammatory responsesearch calcium ion bindingsearch RAGE receptor bindingsearch zinc ion bindingsearch copper ion bindingsearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch