1gpj Summary

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GLUTAMYL-TRNA REDUCTASE FROM METHANOPYRUS KANDLERI

The structure was published by Moser, J., Schubert, W.-D., Beier, V., Bringemeier, I., Jahn, D., and Heinz, D.W., in 2001 in a paper entitled "V-Shaped Structure of Glutamyl-tRNA Reductase, the First Enzyme of tRNA-Dependent Tetrapyrrole Biosynthesis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of GLUTAMYL-TRNA REDUCTASE. This molecule has the UniProt identifier Q9UXR8 (HEM1_METKA)search. The sample contained 404 residues which is 100% of the natural sequence. Out of 404 residues 398 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLUTAMYL-TRNA REDUCTASE Q9UXR8 (1-404) (HEM1_METKA)search Methanopyrus kandleri AV19search 100% 404 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UXR8 (1 - 404) GLUTAMYL-TRNA REDUCTASE Methanopyrus kandleri

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q9UXR8) Glutamyl tRNA-reductase dimerization domainsearch, Aminoacid dehydrogenase-like, C-terminal domainsearch, Glutamyl tRNA-reductase catalytic, N-terminal domainsearch NAD(P)-binding Rossmann-like Domainsearch, Glutamyl-tRNA reductase dimerization domain, domain 3search PF00745: Glutamyl-tRNAGlu reductase, dimerisation domainsearch, PF01488: Shikimate / quinate 5-dehydrogenasesearch, PF05201: Glutamyl-tRNAGlu reductase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q9UXR8) protoporphyrinogen IX biosynthetic processsearch porphyrin-containing compound biosynthetic processsearch oxidation-reduction processsearch tetrapyrrole biosynthetic processsearch oxidoreductase activitysearch NADP bindingsearch glutamyl-tRNA reductase activitysearch

Chain InterPro annotation
A Tetrapyrrole biosynthesis, glutamyl-tRNA reductasesearch Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductasesearch Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminalsearch Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domainsearch NAD(P)-binding domainsearch Glutamyl-tRNA reductase, conserved sitesearch