1gol Summary



The structure was published by Robinson, M.J., Harkins, P.C., Zhang, J., et al., Haycock, J.W., Cobb, M.H., and Goldsmith, E.J., in 1996 in a paper entitled "Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of EXTRACELLULAR REGULATED KINASE 2. This molecule has the UniProt identifier P63086 (MK01_RAT)search. The sample contained 364 residues which is 100% of the natural sequence. Out of 364 residues 357 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EXTRACELLULAR REGULATED KINASE 2 P63086 (1-358) (MK01_RAT)search Rattus norvegicussearch 99% 364 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P63086 (1 - 358) EXTRACELLULAR REGULATED KINASE 2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P63086) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P63086) ATP bindingsearch MAP kinase activitysearch protein bindingsearch transferase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch RNA polymerase II carboxy-terminal domain kinase activitysearch transcription factor bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch protein kinase bindingsearch phosphotyrosine bindingsearch phosphatase bindingsearch mitogen-activated protein kinase kinase kinase bindingsearch protein phosphorylationsearch negative regulation of cell differentiationsearch ERBB signaling pathwaysearch cellular response to organic substancesearch response to epidermal growth factorsearch apoptotic processsearch positive regulation of transcription, DNA-templatedsearch intracellular signal transductionsearch peptidyl-threonine phosphorylationsearch T cell receptor signaling pathwaysearch regulation of Golgi inheritancesearch signal transductionsearch response to lipopolysaccharidesearch regulation of early endosome to late endosome transportsearch sensory perception of painsearch caveolin-mediated endocytosissearch MAPK cascadesearch positive regulation of translationsearch positive regulation of cell proliferationsearch phosphorylationsearch cell cyclesearch peptidyl-serine phosphorylationsearch lipopolysaccharide-mediated signaling pathwaysearch regulation of stress-activated MAPK cascadesearch response to estrogensearch labyrinthine layer blood vessel developmentsearch regulation of protein stabilitysearch cellular response to granulocyte macrophage colony-stimulating factor stimulussearch cytosine metabolic processsearch positive regulation of cell migrationsearch positive regulation of peptidyl-threonine phosphorylationsearch regulation of cytoskeleton organizationsearch ERK1 and ERK2 cascadesearch cellular response to DNA damage stimulussearch B cell receptor signaling pathwaysearch MAPK import into nucleussearch organ morphogenesissearch mammary gland epithelial cell proliferationsearch response to toxic substancesearch response to exogenous dsRNAsearch caveolasearch microtubule organizing centersearch Golgi apparatussearch dendrite cytoplasmsearch nucleussearch cytoplasmsearch spindlesearch cytosolsearch mitochondrionsearch protein complexsearch cytoskeletonsearch nucleoplasmsearch focal adhesionsearch microtubule cytoskeletonsearch pseudopodiumsearch axonsearch extracellular vesicular exosomesearch perikaryonsearch mitotic spindlesearch late endosomesearch early endosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch