1gnh Summary

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HUMAN C-REACTIVE PROTEIN

The structure was published by Shrive, A.K., Cheetham, G.M., Holden, D., et al., Pepys, M.B., Bloomer, A.C., and Greenhough, T.J., in 1996 in a paper entitled "Three dimensional structure of human C-reactive protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of C-REACTIVE PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
B C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
C C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
D C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
E C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
F C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
G C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
H C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
I C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
J C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02741 (19 - 224) C-REACTIVE PROTEIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J (P02741) Pentraxin (pentaxin)search Jelly Rollssearch PF00354: Pentaxin familysearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D, E, F, G, H, I, J (P02741) filopodiumsearch extracellular regionsearch extracellular spacesearch extracellular vesicular exosomesearch growth conesearch virion bindingsearch complement component C1q bindingsearch calcium ion bindingsearch choline bindingsearch protein bindingsearch cholesterol bindingsearch low-density lipoprotein particle bindingsearch metal ion bindingsearch protein homodimerization activitysearch positive regulation of dendrite developmentsearch cellular response to calcium ionsearch defense response to Gram-positive bacteriumsearch acute-phase responsesearch opsonizationsearch complement activation, classical pathwaysearch response to ethanolsearch negative regulation of lipid storagesearch protein polymerizationsearch regulation of interleukin-8 secretionsearch agingsearch response to lead ionsearch inflammatory responsesearch response to hypoxiasearch negative regulation of macrophage derived foam cell differentiationsearch wound healingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J Pentaxinsearch search Concanavalin A-like lectin/glucanase domainsearch