1gnh Summary

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HUMAN C-REACTIVE PROTEIN

The structure was published by Shrive, A.K., Cheetham, G.M., Holden, D., et al., Pepys, M.B., Bloomer, A.C., and Greenhough, T.J., in 1996 in a paper entitled "Three dimensional structure of human C-reactive protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of C-REACTIVE PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
B C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
C C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
D C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
E C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
F C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
G C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
H C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
I C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
J C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02741 (19 - 224) C-REACTIVE PROTEIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J (P02741) Pentraxin (pentaxin)search Jelly Rollssearch PF00354: Pentaxin familysearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G, H, I, J (P02741) filopodiumsearch extracellular regionsearch extracellular spacesearch growth conesearch extracellular exosomesearch negative regulation of lipid storagesearch positive regulation of dendrite developmentsearch regulation of interleukin-8 secretionsearch positive regulation of gene expressionsearch negative regulation of vasodilationsearch protein polymerizationsearch positive regulation of superoxide anion generationsearch cellular response to calcium ionsearch acute-phase responsesearch inflammatory responsesearch wound healingsearch response to hypoxiasearch negative regulation of macrophage derived foam cell differentiationsearch response to lead ionsearch opsonizationsearch agingsearch defense response to Gram-positive bacteriumsearch response to ethanolsearch complement activation, classical pathwaysearch choline bindingsearch calcium ion bindingsearch metal ion bindingsearch low-density lipoprotein particle bindingsearch cholesterol bindingsearch protein bindingsearch low-density lipoprotein particle receptor bindingsearch protein homodimerization activitysearch complement component C1q bindingsearch virion bindingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J Pentaxinsearch Concanavalin A-like lectin/glucanase domainsearch