1gnh Summary

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HUMAN C-REACTIVE PROTEIN

The structure was published by Shrive, A.K., Cheetham, G.M., Holden, D., et al., Pepys, M.B., Bloomer, A.C., and Greenhough, T.J., in 1996 in a paper entitled "Three dimensional structure of human C-reactive protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of C-REACTIVE PROTEIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
B C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
C C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
D C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
E C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
F C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
G C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
H C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
I C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%
J C-REACTIVE PROTEIN P02741 (19-224) (CRP_HUMAN)search Homo sapienssearch 100% 206 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02741 (19 - 224) C-REACTIVE PROTEIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J (P02741) Pentraxin (pentaxin)search Jelly Rollssearch PF00354: Pentaxin familysearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B, C, D, E, F, G, H, I, J (P02741) extracellular spacesearch extracellular regionsearch filopodiumsearch mitochondrionsearch growth conesearch plasma membranesearch cellular response to calcium ionsearch inflammatory responsesearch defense response to Gram-positive bacteriumsearch negative regulation of macrophage derived foam cell differentiationsearch positive regulation of dendrite developmentsearch complement activation, classical pathwaysearch response to lead ionsearch response to ethanolsearch acute-phase responsesearch wound healingsearch cellular response to glucose stimulussearch negative regulation of lipid storagesearch opsonizationsearch response to hypoxiasearch agingsearch protein polymerizationsearch low-density lipoprotein particle bindingsearch protein bindingsearch protein homodimerization activitysearch choline bindingsearch metal ion bindingsearch cholesterol bindingsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J Pentaxinsearch Concanavalin A-like lectin/glucanases superfamilysearch Concanavalin A-like lectin/glucanase, subgroupsearch