› 1gnh

X-ray diffraction
3Å resolution

HUMAN C-REACTIVE PROTEIN

Released:
DOI: 10.2210/pdb1gnh/pdb
PDB entry 1gnh coloured by chain, front view.
PDB entry 1gnh coloured by chain, side view.
PDB entry 1gnh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three dimensional structure of human C-reactive protein.
Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ
Nat Struct Biol 3 346-54 (1996)
PMID: 8599761

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136120 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-reactive protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 206 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02741 (Residues: 19-224; Coverage: 100%)
Gene names: CRP, PTX1
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 16 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 101.06Å b: 154.25Å c: 242.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.239 0.273

Quick links

Citations

61 review citations

Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.
Garlanda et al. (2005)
60 more

22 mentions without citation

Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.
Vasta et al. (2011)
21 more