1gng Summary

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GLYCOGEN SYNTHASE KINASE-3 BETA (GSK3) COMPLEX WITH FRATTIDE PEPTIDE

The structure was published by Bax, B., Carter, P.S., Lewis, C., et al., Brown, M.J.B., Smith, D.G., and Reith, A.D., in 2001 in a paper entitled "The Structure of Phosphorylated Gsk-3Beta Complexed with a Peptide, Frattide, that Inhibits Beta-Catenin Phosphorylation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GLYCOGEN SYNTHASE KINASE-3 BETA and FRATTIDE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (27-393) (GSK3B_HUMAN)search Homo sapienssearch 91% 378 94%
B GLYCOGEN SYNTHASE KINASE-3 BETA P49841 (27-393) (GSK3B_HUMAN)search Homo sapienssearch 91% 378 94%
X FRATTIDE Q92837 (188-226) (FRAT1_HUMAN)search Homo sapienssearch < 90% 39 66%
Y FRATTIDE Q92837 (188-226) (FRAT1_HUMAN)search Homo sapienssearch < 90% 39 66%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P49841 (27 - 393) GLYCOGEN SYNTHASE KINASE-3 BETA Homo sapiens
Q92837 (188 - 226) FRATTIDE HOMO SAPIENS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
X, Y Glycogen synthase kinase-3 bindingsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P49841) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
X, Y Glycogen synthase kinase-3 binding proteinsearch