1glu Summary

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CRYSTALLOGRAPHIC ANALYSIS OF THE INTERACTION OF THE GLUCOCORTICOID RECEPTOR WITH DNA

The structure was published by Luisi, B.F., Xu, W.X., Otwinowski, Z., Freedman, L.P., Yamamoto, K.R., and Sigler, P.B., in 1991 in a paper entitled "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1992.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*TP*CP*GP*AP*TP*GP*TP*TP*C P*TP*G)-3') and PROTEIN (GLUCOCORTICOID RECEPTOR).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (GLUCOCORTICOID RECEPTOR) P06536 (440-514) (GCR_RAT)search Rattus norvegicussearch < 90% 81 100%
B PROTEIN (GLUCOCORTICOID RECEPTOR) P06536 (440-514) (GCR_RAT)search Rattus norvegicussearch < 90% 81 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06536 (440 - 514) PROTEIN (GLUCOCORTICOID RECEPTOR) Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (P06536) nucleussearch calcitriol receptor activitysearch DNA bindingsearch zinc ion bindingsearch sequence-specific DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch