1gli Summary

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DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS)

The structure was published by Vallone, B., Bellelli, A., Miele, A.E., Brunori, M., and Fermi, G., in 1996 in a paper entitled "Probing the alpha 1 beta 2 interface of human hemoglobin by mutagenesis. Role of the FG-C contact regions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DEOXYHEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DEOXYHEMOGLOBIN P69905 (3-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C DEOXYHEMOGLOBIN P69905 (3-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B DEOXYHEMOGLOBIN P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D DEOXYHEMOGLOBIN P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (3 - 142) DEOXYHEMOGLOBIN Homo sapiens
P68871 (3 - 147) DEOXYHEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch oxidation-reduction processsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch membranesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch
B, D (P68871) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch heme bindingsearch oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch peroxidase activitysearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of cell deathsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch oxygen transportsearch renal absorptionsearch protein heterooligomerizationsearch nitric oxide transportsearch blood coagulationsearch response to hydrogen peroxidesearch transportsearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch