1gli Summary

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DEOXYHEMOGLOBIN T38W (ALPHA CHAINS), V1G (ALPHA AND BETA CHAINS)

The structure was published by Vallone, B., Bellelli, A., Miele, A.E., Brunori, M., and Fermi, G., in 1996 in a paper entitled "Probing the alpha 1 beta 2 interface of human hemoglobin by mutagenesis. Role of the FG-C contact regions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DEOXYHEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A DEOXYHEMOGLOBIN P69905 (3-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C DEOXYHEMOGLOBIN P69905 (3-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B DEOXYHEMOGLOBIN P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D DEOXYHEMOGLOBIN P68871 (3-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (3 - 142) DEOXYHEMOGLOBIN Homo sapiens
P68871 (3 - 147) DEOXYHEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch haptoglobin-hemoglobin complexsearch cytosolsearch blood microparticlesearch heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch iron ion bindingsearch haptoglobin bindingsearch metal ion bindingsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch oxygen transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch
B, D (P68871) cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch oxygen bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch oxygen transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch oxidation-reduction processsearch protein heterooligomerizationsearch renal absorptionsearch transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch platelet aggregationsearch nitric oxide transportsearch blood coagulationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch