1gjo Summary

pdbe.org/1gjo
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THE FGFR2 TYROSINE KINASE DOMAIN

A publication describing this structure is not available. The depositing authors are Ceska, T.A.search; Owens, R.search; Doyle, C.search; Hamlyn, P.search; Crabbe, T.search; Moffat, D.search; Davis, J.search; Martin, R.search; Perry, M.J.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of FIBROBLAST GROWTH FACTOR RECEPTOR 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FIBROBLAST GROWTH FACTOR RECEPTOR 2 P21802 (456-768) (FGFR2_HUMAN)search Homo sapienssearch < 90% 316 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P21802 (456 - 768) FIBROBLAST GROWTH FACTOR RECEPTOR 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P21802) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch fibroblast growth factor-activated receptor activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch embryonic cranial skeleton morphogenesissearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Fibroblast growth factor receptor 2search