› 1gjo

X-ray diffraction
2.4Å resolution

The FGFr2 tyrosine kinase domain

Released:
DOI: 10.2210/pdb1gjo/pdb
PDB entry 1gjo coloured by chain, front view.
PDB entry 1gjo coloured by chain, side view.
PDB entry 1gjo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ceska TA, Owens R, Doyle C, Hamlyn P, Crabbe T, Moffat D, Davis J, Martin R, Perry MJ

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149431 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 36.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P21802 (Residues: 456-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: I222
Unit cell:
a: 69.758Å b: 80.983Å c: 120.059Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.256
Expression system: Spodoptera frugiperda

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