1gim Summary

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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI COMPLEXED WITH GDP, IMP, HADACIDIN, NO3-, AND MG2+. DATA COLLECTED AT 100K (PH 6.5)

The structure was published by Poland, B.W., Fromm, H.J., and Honzatko, R.B., in 1996 in a paper entitled "Crystal structures of adenylosuccinate synthetase from Escherichia coli complexed with GDP, IMP hadacidin, NO3-, and Mg2+." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of ADENYLOSUCCINATE SYNTHETASE. This molecule has the UniProt identifier P0A7D4 (PURA_ECOLI)search. The sample contained 431 residues which is 100% of the natural sequence. Out of 431 residues 431 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ADENYLOSUCCINATE SYNTHETASE P0A7D4 (2-432) (PURA_ECOLI)search Escherichia coli K-12search 100% 431 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A7D4 (2 - 432) ADENYLOSUCCINATE SYNTHETASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P0A7D4) Nitrogenase iron protein-likesearch Adenylosuccinate Synthetase, subunit A, domain 1search, Adenylosuccinate Synthetase, subunit A, domain 2search, Adenylosuccinate Synthetase, subunit A, domain 3search PF00709: Adenylosuccinate synthetasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P0A7D4) ligase activitysearch metal ion bindingsearch nucleotide bindingsearch adenylosuccinate synthase activitysearch magnesium ion bindingsearch GTP bindingsearch nucleobase-containing small molecule interconversionsearch purine nucleotide biosynthetic processsearch 'de novo' AMP biosynthetic processsearch cellular response to DNA damage stimulussearch adenosine biosynthetic processsearch IMP metabolic processsearch membranesearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A Adenylosuccinate synthetasesearch Adenylosuccinate synthase, active sitesearch P-loop containing nucleoside triphosphate hydrolasesearch