1gih Summary



The structure was published by Ikuta, M., Kamata, K., Fukasawa, K., et al., Suzuki-Takahashi, I., Hayama, T., and Nishimura, S., in 2001 in a paper entitled "Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 275 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein kinase activitysearch protein serine/threonine kinase activitysearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch kinase activitysearch histone kinase activitysearch transferase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch metal ion bindingsearch meiotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch DNA repairsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch centrosome duplicationsearch Ras protein signal transductionsearch positive regulation of cell proliferationsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic cell cyclesearch protein phosphorylationsearch cell cyclesearch regulation of gene silencingsearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic nuclear divisionsearch phosphorylationsearch histone phosphorylationsearch cellular response to DNA damage stimulussearch cellular response to nitric oxidesearch mitotic G1 DNA damage checkpointsearch cell divisionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch potassium ion transportsearch G2/M transition of mitotic cell cyclesearch meiotic cell cyclesearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch nucleussearch nucleoplasmsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch chromosome, telomeric regionsearch endosomesearch cytoplasmsearch centrosomesearch condensed chromosomesearch cytoskeletonsearch transcription factor complexsearch X chromosomesearch microtubule organizing centersearch Y chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch