1gih Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR

The structure was published by Ikuta, M., Kamata, K., Fukasawa, K., et al., Suzuki-Takahashi, I., Hayama, T., and Nishimura, S., in 2001 in a paper entitled "Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 275 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch positive regulation of transcription, DNA-templatedsearch G1/S transition of mitotic cell cyclesearch cellular response to nitric oxidesearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic G2 phasesearch meiotic nuclear divisionsearch mitotic G1 DNA damage checkpointsearch cell divisionsearch G2/M transition of mitotic cell cyclesearch phosphorylationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch blood coagulationsearch positive regulation of cell proliferationsearch potassium ion transportsearch mitotic nuclear divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch DNA repairsearch centrosome duplicationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch Ras protein signal transductionsearch mitotic cell cyclesearch regulation of gene silencingsearch cell cyclesearch histone phosphorylationsearch cellular response to DNA damage stimulussearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch protein bindingsearch kinase activitysearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch metal ion bindingsearch histone kinase activitysearch cytosolsearch nucleoplasmsearch Y chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch endosomesearch transcription factor complexsearch microtubule organizing centersearch cytoplasmsearch cytoskeletonsearch Cajal bodysearch chromosome, telomeric regionsearch condensed chromosomesearch nucleussearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch