1gih Summary

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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR

The structure was published by Ikuta, M., Kamata, K., Fukasawa, K., et al., Suzuki-Takahashi, I., Hayama, T., and Nishimura, S., in 2001 in a paper entitled "Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 275 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein kinase activitysearch histone kinase activitysearch kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch metal ion bindingsearch cyclin bindingsearch nucleotide bindingsearch transferase activitysearch protein phosphorylationsearch cell cyclesearch phosphorylationsearch mitotic cell cyclesearch regulation of gene silencingsearch cellular response to nitric oxidesearch G1/S transition of mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch DNA replicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cellular response to DNA damage stimulussearch mitotic G1 DNA damage checkpointsearch cell divisionsearch blood coagulationsearch positive regulation of transcription, DNA-templatedsearch mitotic nuclear divisionsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch centrosome duplicationsearch meiotic nuclear divisionsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch Ras protein signal transductionsearch DNA repairsearch positive regulation of cell proliferationsearch potassium ion transportsearch cyclin-dependent protein kinase holoenzyme complexsearch nucleoplasmsearch cytoplasmsearch endosomesearch cytosolsearch condensed chromosomesearch nucleussearch transcription factor complexsearch Cajal bodysearch microtubule organizing centersearch Y chromosomesearch cytoskeletonsearch chromosome, telomeric regionsearch X chromosomesearch centrosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch