1geq Summary

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Entropic stabilization of the tryptophan synthase A-subunit from a hyperthermophile, pyrococcus furiosus: X-ray analysis and calorimetry

The structure was published by Yamagata, Y., Ogasahara, K., Hioki, Y., et al., Ishida, M., Kuramitsu, S., and Yutani, K., in 2001 in a paper entitled "Entropic stabilization of the tryptophan synthase alpha-subunit from a hyperthermophile, Pyrococcus furiosus. X-ray analysis and calorimetry." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of TRYPTOPHAN SYNTHASE ALPHA-SUBUNIT.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TRYPTOPHAN SYNTHASE ALPHA-SUBUNIT Q8U094 (1-248) (TRPA_PYRFU)search Pyrococcus furiosus DSM 3638search 100% 248 98%
B TRYPTOPHAN SYNTHASE ALPHA-SUBUNIT Q8U094 (1-248) (TRPA_PYRFU)search Pyrococcus furiosus DSM 3638search 100% 248 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8U094 (1 - 248) TRYPTOPHAN SYNTHASE ALPHA-SUBUNIT Pyrococcus furiosus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q8U094) Tryptophan biosynthesis enzymessearch Aldolase class Isearch PF00290: Tryptophan synthase alpha chainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (Q8U094) metabolic processsearch aromatic amino acid family biosynthetic processsearch tryptophan biosynthetic processsearch tryptophan metabolic processsearch cellular amino acid biosynthetic processsearch lyase activitysearch tryptophan synthase activitysearch catalytic activitysearch

Chain InterPro annotation
A, B Tryptophan synthase, alpha chainsearch Ribulose-phosphate binding barrelsearch Aldolase-type TIM barrelsearch Tryptophan synthase, alpha chain, active sitesearch