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Entropic stabilization of the tryptophan synthase A-subunit from a hyperthermophile, pyrococcus furiosus: X-ray analysis and calorimetry

X-ray diffraction
2Å resolution
PDB entry 1geq coloured by chain, front view.
PDB entry 1geq coloured by chain, side view.
PDB entry 1geq coloured by chain, top view.
Source organism: Pyrococcus furiosus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tryptophan synthase alpha chain
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Multimeric state: monomeric
Accessible surface area: 11071.84 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186375
Assembly 2
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Assembly Name: Tryptophan synthase alpha chain
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Multimeric state: monomeric
Accessible surface area: 11174.08 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-186375

Macromolecules

Tryptophan synthase alpha chain
Chains: A, B
Length: 248 amino acids
Theoretical weight: 27.54 KDa
Source organism: Pyrococcus furiosus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8U094 (Residues: 1-248; Coverage: 100%)
Gene names: PF1705, trpA
Pfam: Tryptophan synthase alpha chain
InterPro:
CATH: Aldolase class I
SCOP: Tryptophan biosynthesis enzymes
Tryptophan synthase alpha chain in PDB entry 1geq, assembly 1, front view.
Tryptophan synthase alpha chain in PDB entry 1geq, assembly 1, side view.
Tryptophan synthase alpha chain in PDB entry 1geq, assembly 1, top view.
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