1gcq Summary

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CRYSTAL STRUCTURE OF VAV AND GRB2 SH3 DOMAINS

The structure was published by Nishida, M., Nagata, K., Hachimori, Y., et al., Mandiyan, V., Schlessinger, J., and Inagaki, F., in 2001 in a paper entitled "Novel recognition mode between Vav and Grb2 SH3 domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.68 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 and VAV PROTO-ONCOGENE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P62993 (159-217) (GRB2_HUMAN)search Homo sapienssearch 100% 61 93%
B GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P62993 (159-217) (GRB2_HUMAN)search Homo sapienssearch 100% 61 93%
C VAV PROTO-ONCOGENE P27870 (595-660) (VAV_MOUSE)search Mus musculussearch < 90% 70 98%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62993 (159 - 217) GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Homo sapiens
P27870 (595 - 660) VAV PROTO-ONCOGENE Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62993) SH3-domainsearch SH3 Domainssearch PF00018: SH3 domainsearch
C SH3-domainsearch SH3 Domainssearch Variant SH3 domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P62993) SH3/SH2 adaptor activitysearch Ras protein signal transductionsearch membranesearch
C (P27870) small GTPase mediated signal transductionsearch

Chain InterPro annotation
A, B SH3 domainsearch Growth factor receptor-bound protein 2search
C SH3 domainsearch Variant SH3 domainsearch Protein vavsearch