1gcq Summary



The structure was published by Nishida, M., Nagata, K., Hachimori, Y., et al., Mandiyan, V., Schlessinger, J., and Inagaki, F., in 2001 in a paper entitled "Novel recognition mode between Vav and Grb2 SH3 domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.68 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 and VAV PROTO-ONCOGENE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P62993 (159-217) (GRB2_HUMAN)search Homo sapienssearch 100% 61 93%
B GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 P62993 (159-217) (GRB2_HUMAN)search Homo sapienssearch 100% 61 93%
C VAV PROTO-ONCOGENE P27870 (595-660) (VAV_MOUSE)search Mus musculussearch < 90% 70 98%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62993 (159 - 217) GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 Homo sapiens
P27870 (595 - 660) VAV PROTO-ONCOGENE Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62993) SH3-domainsearch SH3 Domainssearch PF00018: SH3 domainsearch
C SH3-domainsearch SH3 Domainssearch Variant SH3 domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P62993) SH3/SH2 adaptor activitysearch Ras protein signal transductionsearch membranesearch
C (P27870) small GTPase mediated signal transductionsearch

Chain InterPro annotation
A, B SH3 domainsearch Growth factor receptor-bound protein 2search
C SH3 domainsearch Variant SH3 domainsearch Protein vavsearch