PDB entry 1gc6

CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE

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The structure was published by Hamada, K., Shimizu, T., Matsui, T., Tsukita, S., and Hakoshima, T., in 2000 in a paper entitled "Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RADIXIN. This molecule has the UniProt identifier P26043 (RADI_MOUSE). The sample contained 297 residues which is < 90% of the natural sequence. Out of 297 residues 296 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain	Name	UniProt	Name of source organism	% of UniProt sequence present in the sample	Residues in the sample molecules	% of residues observed
A	RADIXIN	P26043 (1-297) (RADI_MOUSE)	Mus musculus	< 90%	297	100%

This entry contains 1 unique UniProt protein:

UniProt accession	Name	Organism	PDB
P26043 (1 - 297)	RADIXIN	Mus musculus	Related PDB sequences UniProt coverage

Chain	Structural classification (SCOP)	Structural classification (CATH)	Sequence family (Pfam)
A	First domain of FERM, Second domain of FERM, Third domain of FERM	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1, Acyl-CoA Binding Protein, Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	FERM N-terminal domain , FERM central domain, FERM C-terminal PH-like domain, Ezrin/radixin/moesin family

Chain ID	Molecular function (GO)	Cellular component (GO)
A	Binding, Cytoskeletal protein binding, Protein binding	Cytoplasm, Cytoskeleton, Extrinsic to membrane

Chain	InterPro annotation
A	FERM domain, Ezrin/radixin/moesin family, Moesin, Ezrin/radixin/moesin, Ezrin/radixin/moesin, C-terminal, Pleckstrin homology-like domain, FERM/acyl-CoA-binding protein, 3-helical bundle, FERM, N-terminal, FERM, C-terminal PH-like domain, FERM conserved site, FERM central domain, Band 4.1 domain, Band 4.1 family