1gbv Summary

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(ALPHA-OXY, BETA-(C112G)DEOXY) T-STATE HUMAN HEMOGLOBIN

The structure was published by Vasquez, G.B., Karavitis, M., Ji, X., et al., Brinigar, W.S., Gilliland, G.L., and Fronticelli, C., in 1999 in a paper entitled "Cysteines beta93 and beta112 as probes of conformational and functional events at the human hemoglobin subunit interfaces." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) haptoglobin-hemoglobin complexsearch extracellular regionsearch hemoglobin complexsearch blood microparticlesearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch membranesearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch transportsearch oxygen transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch oxidation-reduction processsearch heme bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch
B, D (P68871) cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch oxygen transportsearch regulation of blood pressuresearch regulation of blood vessel sizesearch nitric oxide transportsearch positive regulation of cell deathsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch platelet aggregationsearch renal absorptionsearch blood coagulationsearch oxidation-reduction processsearch transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch protein bindingsearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen bindingsearch heme bindingsearch peroxidase activitysearch iron ion bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch