1gbu Summary

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DEOXY (BETA-(C93A,C112G)) HUMAN HEMOGLOBIN

The structure was published by Vasquez, G.B., Karavitis, M., Ji, X., et al., Brinigar, W.S., Gilliland, G.L., and Fronticelli, C., in 1999 in a paper entitled "Cysteines beta93 and beta112 as probes of conformational and functional events at the human hemoglobin subunit interfaces." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch protein bindingsearch heme bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch metal ion bindingsearch oxygen transporter activitysearch extracellular vesicular exosomesearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch blood microparticlesearch membranesearch haptoglobin-hemoglobin complexsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch oxygen transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch transportsearch small molecule metabolic processsearch
B, D (P68871) hemoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch peroxidase activitysearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch metal ion bindingsearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch oxygen transportsearch renal absorptionsearch response to hydrogen peroxidesearch bicarbonate transportsearch nitric oxide transportsearch regulation of blood vessel sizesearch oxidation-reduction processsearch positive regulation of cell deathsearch transportsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch blood coagulationsearch protein heterooligomerizationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch