1gag Summary

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CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR

The structure was published by Parang, K., Till, J.H., Ablooglu, A.J., Kohanski, R.A., Hubbard, S.R., and Cole, P.A., in 2001 in a paper entitled "Mechanism-based design of a protein kinase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN RECEPTOR, TYROSINE KINASE DOMAIN and BISUBSTRATE PEPTIDE INHIBITOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN RECEPTOR, TYROSINE KINASE DOMAIN P06213 (1005-1310) (INSR_HUMAN)search Homo sapienssearch < 90% 306 99%
B BISUBSTRATE PEPTIDE INHIBITOR Not available
Not available Not available 13 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06213 (1005 - 1310) INSULIN RECEPTOR, TYROSINE KINASE DOMAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch
B

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P06213) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class II, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch
B