1ga5 Summary

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CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT

The structure was published by Sierk, M.L., Zhao, Q., and Rastinejad, F., in 2001 in a paper entitled "DNA Deformability as a Recognition Feature in the RevErb Response Element" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*(5IT)P*G)-3', and ORPHAN NUCLEAR RECEPTOR NR1D1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ORPHAN NUCLEAR RECEPTOR NR1D1 P20393 (123-216) (NR1D1_HUMAN)search Homo sapienssearch < 90% 94 87%
B ORPHAN NUCLEAR RECEPTOR NR1D1 P20393 (123-216) (NR1D1_HUMAN)search Homo sapienssearch < 90% 94 87%
E ORPHAN NUCLEAR RECEPTOR NR1D1 P20393 (123-216) (NR1D1_HUMAN)search Homo sapienssearch < 90% 94 87%
F ORPHAN NUCLEAR RECEPTOR NR1D1 P20393 (123-216) (NR1D1_HUMAN)search Homo sapienssearch < 90% 94 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P20393 (123 - 216) ORPHAN NUCLEAR RECEPTOR NR1D1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, E, F Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, E, F (P20393) zinc ion bindingsearch sequence-specific DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B, E, F Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch