1g9v Summary

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HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR

The structure was published by Safo, M.K., Moure, C.M., Burnett, J.C., Joshi, G.S., and Abraham, D.J., in 2001 in a paper entitled "High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch bicarbonate transportsearch transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch small molecule metabolic processsearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch
B, D (P68871) bicarbonate transportsearch oxygen transportsearch positive regulation of cell deathsearch renal absorptionsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch blood coagulationsearch transportsearch nitric oxide transportsearch protein heterooligomerizationsearch platelet aggregationsearch small molecule metabolic processsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch heme bindingsearch protein bindingsearch oxygen bindingsearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin bindingsearch blood microparticlesearch hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch