1g9v Summary

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HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR

The structure was published by Safo, M.K., Moure, C.M., Burnett, J.C., Joshi, G.S., and Abraham, D.J., in 2001 in a paper entitled "High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch response to hydrogen peroxidesearch blood microparticlesearch cytosolic small ribosomal subunitsearch membranesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular exosomesearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch protein bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch heme bindingsearch
B, D (P68871) oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch small molecule metabolic processsearch nitric oxide transportsearch platelet aggregationsearch renal absorptionsearch protein heterooligomerizationsearch regulation of blood pressuresearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch oxidation-reduction processsearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch transportsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch extracellular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch