1g9v Summary

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HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXY HEMOGLOBIN COMPLEXED WITH A POTENT ALLOSTERIC EFFECTOR

The structure was published by Safo, M.K., Moure, C.M., Burnett, J.C., Joshi, G.S., and Abraham, D.J., in 2001 in a paper entitled "High-resolution crystal structure of deoxy hemoglobin complexed with a potent allosteric effector." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch protein bindingsearch iron ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch oxidation-reduction processsearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch transportsearch small molecule metabolic processsearch oxygen transportsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch
B, D (P68871) protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin bindingsearch iron ion bindingsearch heme bindingsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch bicarbonate transportsearch blood coagulationsearch platelet aggregationsearch nitric oxide transportsearch protein heterooligomerizationsearch renal absorptionsearch small molecule metabolic processsearch oxygen transportsearch response to hydrogen peroxidesearch transportsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch positive regulation of cell deathsearch oxidation-reduction processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch