1g8i Summary

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CRYSTAL STRUCTURE OF HUMAN FREQUENIN (NEURONAL CALCIUM SENSOR 1)

The structure was published by Bourne, Y., Dannenberg, J., Pollmann, V., Marchot, P., and Pongs, O., in 2001 in a paper entitled "Immunocytochemical localization and crystal structure of human frequenin (neuronal calcium sensor 1)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of NEURONAL CALCIUM SENSOR 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEURONAL CALCIUM SENSOR 1 P62166 (1-190) (NCS1_HUMAN)search Homo sapienssearch 96% 190 97%
B NEURONAL CALCIUM SENSOR 1 P62166 (1-190) (NCS1_HUMAN)search Homo sapienssearch 96% 190 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62166 (1 - 190) NEURONAL CALCIUM SENSOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P62166) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P62166) calcium ion bindingsearch voltage-gated calcium channel activitysearch protein bindingsearch magnesium ion bindingsearch protein kinase bindingsearch metal ion bindingsearch plasma membranesearch cell junctionsearch perinuclear region of cytoplasmsearch extracellular vesicular exosomesearch dendritesearch cytoplasmic vesiclesearch axonsearch cytoplasmsearch postsynaptic membranesearch intracellular membrane-bounded organellesearch postsynaptic densitysearch membranesearch Golgi apparatussearch synapsesearch Golgi cisterna membranesearch cytosolsearch regulation of neuron projection developmentsearch calcium ion transmembrane transportsearch positive regulation of exocytosissearch phosphatidylinositol-mediated signalingsearch

Chain InterPro annotation
A, B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch Recoverin familysearch