1g5y Summary

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THE 2.0 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN TETRAMER IN THE PRESENCE OF A NON-ACTIVATING RETINOIC ACID ISOMER.

The structure was published by Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Wisely, G.B., Milburn, M.V., and Xu, H.E., in 2000 in a paper entitled "Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of RETINOIC ACID RECEPTOR RXR-ALPHA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%
B RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%
C RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%
D RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19793 (225 - 462) RETINOIC ACID RECEPTOR RXR-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P19793) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P19793) zinc ion bindingsearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B, C, D Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch