1g5s Summary



The structure was published by Dreyer, M.K., Borcherding, D.R., Dumont, J.A., et al., Bitonti, A.J., Shen, J., and Kim, S.H., in 2001 in a paper entitled "Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.61 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein serine/threonine kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch metal ion bindingsearch cyclin bindingsearch transferase activitysearch nucleotide bindingsearch kinase activitysearch histone kinase activitysearch protein phosphorylationsearch regulation of gene silencingsearch cellular response to nitric oxidesearch cell divisionsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic cell cyclesearch centrosome duplicationsearch mitotic nuclear divisionsearch blood coagulationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch phosphorylationsearch Ras protein signal transductionsearch histone phosphorylationsearch DNA replicationsearch G1/S transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch mitotic G1 DNA damage checkpointsearch mitotic G2 phasesearch DNA repairsearch meiotic nuclear divisionsearch G2/M transition of mitotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to DNA damage stimulussearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch cell cyclesearch positive regulation of cell proliferationsearch potassium ion transportsearch nucleoplasmsearch Y chromosomesearch nucleussearch X chromosomesearch cytoplasmsearch centrosomesearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch cytoskeletonsearch chromosome, telomeric regionsearch condensed chromosomesearch endosomesearch microtubule organizing centersearch transcription factor complexsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch