1g48 Summary

pdbe.org/1g48
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE

The structure was published by Kim, C.-Y., Chang, J.S., Doyon, J.B., et al., Fierke, C.A., Jain, A., and Christianson, D.W., in 2000 in a paper entitled "Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.86 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) microvillussearch extracellular vesicular exosomesearch membranesearch myelin sheathsearch plasma membranesearch cytoplasmsearch axonsearch basolateral plasma membranesearch cytosolsearch apical part of cellsearch extracellular spacesearch carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch lyase activitysearch protein bindingsearch response to organic substancesearch bicarbonate transportsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch positive regulation of cellular pH reductionsearch regulation of intracellular pHsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch response to pHsearch regulation of anion transportsearch small molecule metabolic processsearch response to estrogensearch secretionsearch response to zinc ionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch