1g45 Summary

pdbe.org/1g45
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE

The structure was published by Kim, C.-Y., Chang, J.S., Doyon, J.B., et al., Fierke, C.A., Jain, A., and Christianson, D.W., in 2000 in a paper entitled "Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.83 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytosolsearch cytoplasmsearch extracellular vesicular exosomesearch membranesearch basolateral plasma membranesearch apical part of cellsearch axonsearch myelin sheathsearch plasma membranesearch extracellular spacesearch microvillussearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch kidney developmentsearch regulation of intracellular pHsearch response to zinc ionsearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch response to estrogensearch secretionsearch response to steroid hormonesearch response to organic substancesearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch response to pHsearch small molecule metabolic processsearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch carbonate dehydratase activitysearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch