1g3n Summary

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STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX

The structure was published by Jeffrey, P.D., Tong, L., and Pavletich, N.P., in 2000 in a paper entitled "Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE 6 INHIBITOR, and V-CYCLIN.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE 6 Q00534 (1-326) (CDK6_HUMAN)search Homo sapienssearch 92% 326 89%
E CYCLIN-DEPENDENT KINASE 6 Q00534 (1-326) (CDK6_HUMAN)search Homo sapienssearch 92% 326 89%
B CYCLIN-DEPENDENT KINASE 6 INHIBITOR P42773 (1-168) (CDN2C_HUMAN)search Homo sapienssearch 96% 168 92%
F CYCLIN-DEPENDENT KINASE 6 INHIBITOR P42773 (1-168) (CDN2C_HUMAN)search Homo sapienssearch 96% 168 92%
C V-CYCLIN Q98147 (1-257) (Q98147_HHV8)search Human herpesvirus 8search 100% 257 90%
G V-CYCLIN Q98147 (1-257) (Q98147_HHV8)search Human herpesvirus 8search 100% 257 90%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q00534 (1 - 326) CYCLIN-DEPENDENT KINASE 6 Homo sapiens
P42773 (1 - 168) CYCLIN-DEPENDENT KINASE 6 INHIBITOR Homo sapiens
Q98147 (1 - 257) V-CYCLIN Human herpesvirus 8

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E (Q00534) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B, F (P42773) Ankyrin repeatsearch Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeatsearch PF00023: Ankyrin repeatsearch
C, G Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, K cyclin, C terminalsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, E (Q00534) kinase activitysearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch ATP bindingsearch cyclin bindingsearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch regulation of erythrocyte differentiationsearch G1/S transition of mitotic cell cyclesearch positive regulation of fibroblast proliferationsearch dentate gyrus developmentsearch negative regulation of cell differentiationsearch type B pancreatic cell developmentsearch cell cycle arrestsearch cell dedifferentiationsearch phosphorylationsearch response to virussearch negative regulation of myeloid cell differentiationsearch negative regulation of osteoblast differentiationsearch mitotic cell cyclesearch regulation of gene expressionsearch gliogenesissearch generation of neuronssearch cell cyclesearch negative regulation of cellular senescencesearch regulation of cell motilitysearch astrocyte developmentsearch negative regulation of epithelial cell proliferationsearch cell divisionsearch cell differentiationsearch positive regulation of cell-matrix adhesionsearch negative regulation of cell proliferationsearch negative regulation of cell cyclesearch lateral ventricle developmentsearch protein phosphorylationsearch nucleussearch cytoplasmsearch cell projectionsearch rufflesearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch nucleolussearch
B, F (P42773) protein bindingsearch cyclin-dependent protein serine/threonine kinase inhibitor activitysearch protein kinase bindingsearch negative regulation of cell proliferationsearch cell cyclesearch negative regulation of phosphorylationsearch oligodendrocyte differentiationsearch mitotic cell cyclesearch negative regulation of cell growthsearch negative regulation of protein serine/threonine kinase activitysearch cell cycle arrestsearch G1/S transition of mitotic cell cyclesearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch cytosolsearch cytoplasmsearch nucleussearch
C, G (Q98147) protein bindingsearch

Chain InterPro annotation
A, E Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Cyclin-dependent kinase 6search
B, F Ankyrin repeatsearch Ankyrin repeat-containing domainsearch
C, G Cyclin, N-terminalsearch Cyclin-likesearch K cyclin, C-terminalsearch Cyclin, herpesvirussearch