1g3j Summary

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CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX

The structure was published by Graham, T.A., Weaver, C., Mao, F., Kimelman, D., and Xu, W., in 2000 in a paper entitled "Crystal structure of a beta-catenin/Tcf complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely BETA-CATENIN ARMADILLO REPEAT REGION and TCF3-CBD (CATENIN BINDING DOMAIN).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A BETA-CATENIN ARMADILLO REPEAT REGION P35222 (133-664) (CTNB1_HUMAN)search Homo sapienssearch < 90% 532 98%
C BETA-CATENIN ARMADILLO REPEAT REGION P35222 (133-664) (CTNB1_HUMAN)search Homo sapienssearch < 90% 532 98%
B TCF3-CBD (CATENIN BINDING DOMAIN) P70062 (1-61) (T7L1A_XENLA)search Xenopus laevissearch < 90% 61 67%
D TCF3-CBD (CATENIN BINDING DOMAIN) P70062 (1-61) (T7L1A_XENLA)search Xenopus laevissearch < 90% 61 67%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P35222 (133 - 664) BETA-CATENIN ARMADILLO REPEAT REGION Homo sapiens
P70062 (1 - 61) TCF3-CBD (CATENIN BINDING DOMAIN) Xenopus laevis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C Armadillo repeatsearch Leucine-rich Repeat Variantsearch Armadillo/beta-catenin-like repeatsearch
B, D beta-Catenine bound non-globular protein regionssearch TCF3-CBD (Catenin binding domain)search N-terminal CTNNB1 bindingsearch

Chain ID Biological process (GO)
B, D (P70062) Wnt signaling pathwaysearch

Chain InterPro annotation
A, C Armadillosearch Armadillo-like helicalsearch Beta-cateninsearch Armadillo-type foldsearch
B, D CTNNB1 binding, N-teminalsearch Transcription factor TCF/LEFsearch Catenin binding domainsearch