› 1g1u

X-ray diffraction
2.5Å resolution

THE 2.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN IN TETRAMER IN THE ABSENCE OF LIGAND

Released:
DOI: 10.2210/pdb1g1u/pdb
PDB entry 1g1u coloured by chain, front view.
PDB entry 1g1u coloured by chain, side view.
PDB entry 1g1u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix.
Gampe RT, Montana VG, Lambert MH, Wisely GB, Milburn MV, Xu HE
Genes Dev 14 2229-41 (2000)
PMID: 10970886

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148730 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoic acid receptor RXR-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 238 amino acids
Theoretical weight: 26.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19793 (Residues: 225-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 51.057Å b: 99.305Å c: 94.98Å
α: 90° β: 97.38° γ: 90°
R-values:
R R work R free
0.22 0.22 0.271
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Peroxisome proliferator-activated receptor gamma and metabolic disease.
Willson et al. (2001)
12 more

13 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
12 more