1g1u Summary

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THE 2.5 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE RXRALPHA LIGAND BINDING DOMAIN IN TETRAMER IN THE ABSENCE OF LIGAND

The structure was published by Gampe Jr., R.T., Montana, V.G., Lambert, M.H., Wisely, G.B., Milburn, M.V., and Xu, H.E., in 2000 in a paper entitled "Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of RETINOIC ACID RECEPTOR RXR-ALPHA.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%
B RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%
C RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%
D RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19793 (225 - 462) RETINOIC ACID RECEPTOR RXR-ALPHA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P19793) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P19793) DNA bindingsearch steroid hormone receptor activitysearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A, B, C, D Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch