1g1d Summary

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CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE

The structure was published by Kim, C.-Y., Chang, J.S., Doyon, J.B., et al., Fierke, C.A., Jain, A., and Christianson, D.W., in 2000 in a paper entitled "Contribution of Fluorine to Protein-Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch positive regulation of synaptic transmission, GABAergicsearch regulation of anion transportsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch bicarbonate transportsearch response to organic substancesearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch response to estrogensearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch kidney developmentsearch response to pHsearch secretionsearch odontogenesis of dentin-containing toothsearch regulation of intracellular pHsearch response to steroid hormonesearch plasma membranesearch apical part of cellsearch cytosolsearch cytoplasmsearch axonsearch myelin sheathsearch extracellular vesicular exosomesearch extracellular spacesearch membranesearch basolateral plasma membranesearch microvillussearch zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch