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EBI PDBe PDBeView

PDBe Entry: 1fzf view

CRYSTAL STRUCTURE OF FRAGMENT DOUBLE-D FROM HUMAN FIBRIN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE
Summary
Header BLOOD COAGULATIONsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.7 Å, R-factor: 23.3%, Free R-factor: 30.2%, Spacegroup: P 21 21 21
Released 08/06/1999, deposition: 28/12/1998, last revision: 24/02/2009
Authors Everse, S.J.search; Spraggon, G.search; Veerapandian, L.search; Doolittle, R.F.search
Primary citation Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
BIOCHEMISTRYsearch vol:38, pag:2941-2946 (1999) [PubMed ID 10074346 ]search
Keywords BLOOD COAGULATIONsearch, PLASMAsearch, PLATELETsearch, FIBRINOGENsearch, FIBRINsearch
Organism Homo sapiens(human) 9606search(A D B E C F S T M N)
UniProt Fibrinogen alpha chain precursor [Contains: Fibrinopeptide A] P02671search (A D)
Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] P02675search (B E S T M N)
Fibrinogen gamma chain precursor P02679search (C F)
Polymers
Id Name Type UniProt Residues Observed
A, D FIBRINOGEN Protein P02671 (FIBA_HUMAN)search
 87 77%
B, E FIBRINOGEN Protein P02675 (FIBB_HUMAN)search
 328 92%
C, F FIBRINOGEN Protein P02679 (FIBG_HUMAN)search
 319 91%
S, T, M, N FIBRINOGEN Protein P02675 (FIBB_HUMAN)search
 4 100%
Heterogens
Id Name Ligands
B, E SUGAR (N-ACETYL-D-GLUCOSAMINE) NAG search
B, C, E, F CALCIUM ION CA search
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