› 1fzb

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF CROSSLINKED FRAGMENT D

Released:
DOI: 10.2210/pdb1fzb/pdb
PDB entry 1fzb coloured by chain, front view.
PDB entry 1fzb coloured by chain, side view.
PDB entry 1fzb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.
Spraggon G, Everse SJ, Doolittle RF
Nature 389 455-62 (1997)
PMID: 9333233

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136025 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Fibrinogen alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 87 amino acids
Theoretical weight: 10.24 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02671 (Residues: 130-216; Coverage: 10%)
Gene name: FGA
Sequence domains: Fibrinogen alpha/beta chain family
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Fibrinogen beta chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 328 amino acids
Theoretical weight: 37.69 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02675 (Residues: 164-491; Coverage: 71%)
Gene name: FGB
Sequence domains:
Structure domains:
Fibrinogen gamma chain Chains: C, F
Molecule details ›
Chains: C, F
Length: 319 amino acids
Theoretical weight: 36.22 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02679 (Residues: 115-432; Coverage: 75%)
Gene names: FGG, PRO2061
Sequence domains:
Structure domains:
PEPTIDE LIGAND GPRG Chains: G, H
Molecule details ›
Chains: G, H
Length: 4 amino acids
Theoretical weight: 426 Da

Ligands and Environments

2 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P21
Unit cell:
a: 93.82Å b: 95.5Å c: 113.76Å
α: 90° β: 96.08° γ: 90°
R-values:
R R work R free
0.241 0.241 0.318

Quick links

Citations

41 review citations

Fibrinogen and fibrin structure and functions.
Mosesson MW. (2005)
40 more

8 mentions without citation

Crossing borders to bind proteins--a new concept in protein recognition based on the conjugation of small organic molecules or short peptides to polypeptides from a designed set.
Baltzer L. (2011)
7 more