1fza Summary

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CRYSTAL STRUCTURE OF FIBRINOGEN FRAGMENT D

The structure was published by Spraggon, G., Everse, S.J., and Doolittle, R.F., in 1997 in a paper entitled "Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely FIBRINOGEN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FIBRINOGEN P02671 (130-216) (FIBA_HUMAN)search Homo sapienssearch < 90% 87 97%
D FIBRINOGEN P02671 (130-216) (FIBA_HUMAN)search Homo sapienssearch < 90% 87 97%
B FIBRINOGEN P02675 (164-491) (FIBB_HUMAN)search Homo sapienssearch 99% 328 95%
E FIBRINOGEN P02675 (164-491) (FIBB_HUMAN)search Homo sapienssearch 99% 328 95%
C FIBRINOGEN P02679 (114-432) (FIBG_HUMAN)search Homo sapienssearch 95% 319 96%
F FIBRINOGEN P02679 (114-432) (FIBG_HUMAN)search Homo sapienssearch 95% 319 96%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P02671 (130 - 216) FIBRINOGEN Homo sapiens
P02675 (164 - 491) FIBRINOGEN Homo sapiens
P02679 (114 - 432) FIBRINOGEN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D Fibrinogen coiled-coil and central regionssearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch Fibrinogen alpha/beta chain familysearch
B, E (P02675) Fibrinogen C-terminal domain-likesearch, Fibrinogen coiled-coil and central regionssearch Gamma Fibrinogen, chain A, domain 1search, Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2search PF00147: Fibrinogen beta and gamma chains, C-terminal globular domainsearch, PF08702: Fibrinogen alpha/beta chain familysearch
C, F (P02679) Fibrinogen C-terminal domain-likesearch, Fibrinogen coiled-coil and central regionssearch Gamma Fibrinogen, chain A, domain 1search, Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2search PF00147: Fibrinogen beta and gamma chains, C-terminal globular domainsearch, PF08702: Fibrinogen alpha/beta chain familysearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, D (P02671) receptor bindingsearch protein binding, bridgingsearch fibrinogen complexsearch signal transductionsearch platelet activationsearch protein polymerizationsearch
B, E (P02675) receptor bindingsearch protein binding, bridgingsearch fibrinogen complexsearch signal transductionsearch platelet activationsearch protein polymerizationsearch
C, F (P02679) receptor bindingsearch protein binding, bridgingsearch fibrinogen complexsearch signal transductionsearch platelet activationsearch protein polymerizationsearch

Chain InterPro annotation
A, D Fibrinogen, alpha/beta/gamma chain, coiled coil domainsearch
B, E Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainsearch Fibrinogen, alpha/beta/gamma chain, coiled coil domainsearch Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2search Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1search Fibrinogen, conserved sitesearch
C, F Fibrinogen, alpha/beta/gamma chain, C-terminal globular domainsearch Fibrinogen, alpha/beta/gamma chain, coiled coil domainsearch Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2search Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1search Fibrinogen, conserved sitesearch