1fyh Summary

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1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

The structure was published by Randal, M. and Kossiakoff, A.A., in 2001 in a paper entitled "The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON-GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
D INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
B INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (28 - 156) INTERFERON-GAMMA Homo sapiens
P15260 (18 - 246) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
B, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, D (P01579) immune responsesearch negative regulation of cell proliferationsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of tumor necrosis factor productionsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch interferon-gamma-mediated signaling pathwaysearch response to virussearch endoplasmic reticulum unfolded protein responsesearch inflammatory cell apoptotic processsearch defense response to virussearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch apoptotic processsearch negative regulation of epithelial cell differentiationsearch negative regulation of growth of symbiont in hostsearch regulation of the force of heart contractionsearch negative regulation of smooth muscle cell proliferationsearch cellular component movementsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of interleukin-12 productionsearch cellular response to interleukin-18search defense response to bacteriumsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch humoral immune responsesearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of interleukin-6 biosynthetic processsearch response to drugsearch positive regulation of interleukin-23 productionsearch regulation of interferon-gamma-mediated signaling pathwaysearch neutrophil apoptotic processsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of synaptic transmission, cholinergicsearch neutrophil chemotaxissearch regulation of transcription, DNA-templatedsearch positive regulation of isotype switching to IgG isotypessearch negative regulation of interleukin-17 productionsearch positive regulation of neuron differentiationsearch positive regulation of interleukin-1 beta secretionsearch antigen processing and presentationsearch positive regulation of chemokine biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch adaptive immune responsesearch positive regulation of transcription, DNA-templatedsearch positive regulation of MHC class II biosynthetic processsearch negative regulation of myelinationsearch positive regulation of membrane protein ectodomain proteolysissearch regulation of insulin secretionsearch cytokine-mediated signaling pathwaysearch positive regulation of mesenchymal cell proliferationsearch positive regulation of T cell proliferationsearch regulation of immune responsesearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of osteoclast differentiationsearch cell surface receptor signaling pathwaysearch regulation of growthsearch positive regulation of killing of cells of other organismsearch cellular response to lipopolysaccharidesearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch protein import into nucleus, translocationsearch extrinsic apoptotic signaling pathwaysearch positive regulation of cell adhesionsearch defense response to protozoansearch cell cycle arrestsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch positive regulation of cell proliferationsearch positive regulation of vitamin D biosynthetic processsearch extracellular regionsearch external side of plasma membranesearch extracellular spacesearch cytokine activitysearch interferon-gamma receptor bindingsearch
B, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch