1fyh Summary

pdbe.org/1fyh
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1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

The structure was published by Randal, M. and Kossiakoff, A.A., in 2001 in a paper entitled "The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON-GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
D INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
B INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (28 - 156) INTERFERON-GAMMA Homo sapiens
P15260 (18 - 246) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
B, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, D (P01579) positive regulation of isotype switching to IgG isotypessearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch apoptotic processsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch negative regulation of epithelial cell differentiationsearch interferon-gamma-mediated signaling pathwaysearch positive regulation of transcription, DNA-templatedsearch positive regulation of neuron differentiationsearch positive regulation of cell adhesionsearch negative regulation of smooth muscle cell proliferationsearch cellular component movementsearch response to virussearch positive regulation of nitric oxide biosynthetic processsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of interleukin-12 productionsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch inflammatory cell apoptotic processsearch humoral immune responsesearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch defense response to virussearch positive regulation of interleukin-23 productionsearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of T cell proliferationsearch negative regulation of cell proliferationsearch regulation of transcription, DNA-templatedsearch negative regulation of interleukin-17 productionsearch cytokine-mediated signaling pathwaysearch positive regulation of interleukin-1 beta secretionsearch adaptive immune responsesearch positive regulation of membrane protein ectodomain proteolysissearch cellular response to interleukin-18search positive regulation of mesenchymal cell proliferationsearch regulation of insulin secretionsearch negative regulation of growth of symbiont involved in interaction with hostsearch regulation of the force of heart contractionsearch defense response to bacteriumsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch cellular response to lipopolysaccharidesearch regulation of immune responsesearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of osteoclast differentiationsearch cell surface receptor signaling pathwaysearch antigen processing and presentationsearch negative regulation of myelinationsearch regulation of growthsearch extrinsic apoptotic signaling pathwaysearch negative regulation of growth of symbiont in hostsearch positive regulation of chemokine biosynthetic processsearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of synaptic transmission, cholinergicsearch cell cycle arrestsearch neutrophil chemotaxissearch positive regulation of tumor necrosis factor productionsearch neutrophil apoptotic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of MHC class II biosynthetic processsearch protein import into nucleus, translocationsearch immune responsesearch positive regulation of killing of cells of other organismsearch response to drugsearch defense response to protozoansearch positive regulation of cell proliferationsearch positive regulation of vitamin D biosynthetic processsearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch cytokine activitysearch interferon-gamma receptor bindingsearch
B, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch