1fyh Summary

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1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

The structure was published by Randal, M. and Kossiakoff, A.A., in 2001 in a paper entitled "The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON-GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
D INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
B INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (28 - 156) INTERFERON-GAMMA Homo sapiens
P15260 (18 - 246) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
B, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, D (P01579) extracellular regionsearch extracellular spacesearch external side of plasma membranesearch immune responsesearch regulation of the force of heart contractionsearch positive regulation of transcription, DNA-templatedsearch antigen processing and presentationsearch regulation of hepatocyte proliferationsearch regulation of neuronal action potentialsearch neutrophil chemotaxissearch response to drugsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of interleukin-1 beta secretionsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of neuron differentiationsearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch defense response to virussearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch interferon-gamma-mediated signaling pathwaysearch apoptotic processsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch negative regulation of epithelial cell differentiationsearch negative regulation of smooth muscle cell proliferationsearch movement of cell or subcellular componentsearch positive regulation of interleukin-12 productionsearch response to virussearch humoral immune responsesearch adaptive immune responsesearch cellular response to lipopolysaccharidesearch negative regulation of interleukin-17 productionsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of mesenchymal cell proliferationsearch positive regulation of cell adhesionsearch positive regulation of MHC class II biosynthetic processsearch sensory perception of mechanical stimulussearch regulation of immune responsesearch positive regulation of chemokine biosynthetic processsearch regulation of transcription, DNA-templatedsearch cellular response to interleukin-18search defense response to bacteriumsearch inflammatory cell apoptotic processsearch negative regulation of growth of symbiont in hostsearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of interleukin-23 productionsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of myelinationsearch endoplasmic reticulum unfolded protein responsesearch cytokine-mediated signaling pathwaysearch neutrophil apoptotic processsearch regulation of growthsearch regulation of insulin secretionsearch positive regulation of membrane protein ectodomain proteolysissearch negative regulation of growth of symbiont involved in interaction with hostsearch negative regulation of cell proliferationsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of isotype switching to IgG isotypessearch extrinsic apoptotic signaling pathwaysearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of tumor necrosis factor productionsearch positive regulation of osteoclast differentiationsearch cell surface receptor signaling pathwaysearch defense response to protozoansearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch cell cycle arrestsearch protein import into nucleus, translocationsearch positive regulation of killing of cells of other organismsearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of cell proliferationsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of T cell proliferationsearch cytokine activitysearch interferon-gamma receptor bindingsearch
B, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch