1fyh Summary

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1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR

The structure was published by Randal, M. and Kossiakoff, A.A., in 2001 in a paper entitled "The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.04 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON-GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
D INTERFERON-GAMMA P01579 (28-156) (IFNG_HUMAN)search Homo sapienssearch 90% 258 93%
B INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-246) (INGR1_HUMAN)search Homo sapienssearch < 90% 229 87%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (28 - 156) INTERFERON-GAMMA Homo sapiens
P15260 (18 - 246) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, D (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
B, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, D (P01579) positive regulation of mesenchymal cell proliferationsearch regulation of insulin secretionsearch cytokine-mediated signaling pathwaysearch negative regulation of growth of symbiont involved in interaction with hostsearch negative regulation of cell proliferationsearch antigen processing and presentationsearch cellular response to lipopolysaccharidesearch defense response to virussearch cell cycle arrestsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of osteoclast differentiationsearch cell surface receptor signaling pathwaysearch regulation of growthsearch extrinsic apoptotic signaling pathwaysearch humoral immune responsesearch positive regulation of transcription, DNA-templatedsearch apoptotic processsearch protein import into nucleus, translocationsearch regulation of the force of heart contractionsearch positive regulation of killing of cells of other organismsearch positive regulation of cell proliferationsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch immune responsesearch positive regulation of interleukin-12 productionsearch response to virussearch adaptive immune responsesearch negative regulation of myelinationsearch negative regulation of smooth muscle cell proliferationsearch movement of cell or subcellular componentsearch negative regulation of epithelial cell differentiationsearch positive regulation of tumor necrosis factor productionsearch neutrophil chemotaxissearch interferon-gamma-mediated signaling pathwaysearch response to drugsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of MHC class II biosynthetic processsearch regulation of neuronal action potentialsearch positive regulation of cell adhesionsearch positive regulation of transcription from RNA polymerase II promotersearch defense response to bacteriumsearch positive regulation of interleukin-6 biosynthetic processsearch sensory perception of mechanical stimulussearch neutrophil apoptotic processsearch positive regulation of isotype switching to IgG isotypessearch negative regulation of growth of symbiont in hostsearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of interleukin-1 beta secretionsearch regulation of hepatocyte proliferationsearch inflammatory cell apoptotic processsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of T cell proliferationsearch positive regulation of neuron differentiationsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch regulation of interferon-gamma-mediated signaling pathwaysearch regulation of immune responsesearch positive regulation of interleukin-23 productionsearch cellular response to interleukin-18search regulation of transcription, DNA-templatedsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of chemokine biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of interleukin-12 biosynthetic processsearch negative regulation of interleukin-17 productionsearch defense response to protozoansearch positive regulation of membrane protein ectodomain proteolysissearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch interferon-gamma receptor bindingsearch cytokine activitysearch
B, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, D Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch